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KMID : 0377220030280010073
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Medical Journal of Chosun Univercity
2003 Volume.28 No. 1 p.73 ~ p.78
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Clinicopathologic characteristics of early (40-year old or younger) onset mammary infiltrating ductal carcinoma
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Choi Eun-Seo
Kim Kweon-Cheon
Jo Hyun-Jin
Kim Seong-Hwan
Min Young-Don
Jang Jeong-Hwan
Kim Kyung-Jong
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Abstract
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Purposes : It is controversial whether breast cancer in young women is more aggressive than that in older women this study was performed to investigate characteristic prognostic factors of early onset breast cancer and correlated factors with prognosis of young age
Method : Between 1996 and 2002, a retrospective study of 106 patients with breast cancer, underwent operation in Department of Surgery, Chosun University Hospital was conducted. The patients were divided into two groups, yound age group(<40 yr) and old age group(> yr).
We investigated TNM stage, tumor size, number of lymph node metastasis(N-stage), histologic grades, hormonal receptor, PTEN and HER-2/neu expressions and NPI(Nottingham Prognostic Index) and compared them between two groups.
Results : The 27 patients were included in the young age group(median age. 36 yr) and 79 in the old age group(median age. 54 yr) The young age group had more advanced N-stage(N2, N3) and more poor histologic grade(grade Ⅲ) than the old age group with significancy(P<0.05). There were no differences in TNM stage, tumor size, hormone receptor, PTEN and HER-2/neu expressions and NPI between two groups.
Conclusion : Prognostic factors(histologic or biologic factor) are more likely to be found in breast cancers of young women and it is implicated the young patients with breast cancer have more poor prognosis than in older patients.
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KEYWORD
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Young age, Histologic grade, Lymph node metastasis, Prognosis
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